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[亨利（埃德蒙·戈温EdmundGwenn饰）和女儿西尔维娅（凯瑟琳·赫本KatharineHepburn饰）一起过着相依为命的日子。受生活所迫，亨利挪用了公款无法还债，东窗事发之后，他和女儿一起隐姓埋名踏上了逃亡之旅，途中，为了隐藏身份，西尔维娅女扮男装，易名赛尔维斯特。在逃亡途中，亨利和西尔维娅结识了名为吉米（加里·格兰特CaryGrant饰）的男子，吉米也是一个骗子，气味相投一拍即合的一行人结为了旅伴。之后，提尔特（娜塔丽·帕蕾NataliePaley饰）也加入了他们的行列，好笑的是，虽然朝夕相处，但没有一个人能够识破西尔维娅的伪装，直到一位名为迈克尔（布赖恩·艾亨BrianAherne饰）的艺术家出现了。]

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卡洛琳·班德（Hope Lange）是一个刚毕业不久、在纽约打拼的女大学生，她进入费边出版公司担任秘书职位，并在那里认识了同样身为秘书的格雷格·亚当斯（Suzy Parker）和阿普里尔·莫里森（Diane Baker），格雷格和阿普里尔都很喜欢卡洛琳，于是邀请卡洛琳搬进她们的公寓，三个女孩就这样生活在了一起。卡洛琳的上司阿曼达·法罗（Joan Crawford）因为怀疑卡洛琳企图取代她的位置，所以一直百般刁难卡洛琳，然而卡洛琳自己却计划男友艾迪·哈里斯（Brett Halsey）一从欧洲回来便与其成婚，然后从公司辞职彻底投入家庭主妇的生活，但天不遂人愿的是艾迪在欧洲与其他女人成婚，伤心不已的卡洛琳只好全心投入工作之中，她和编辑迈克·莱斯（Stephen Boyd）的感情也因此变得越发复杂。阿普里尔是个天真单纯的女孩，刚一入公司就遭到了上司沙利马尔先生(Brian Aherne)的性骚扰，但却反而与其成为朋友，后来偶然间她认识了富二代德克斯特·基（Robert Evans）并与其交往，她幻想着与之成家立业却未料到自己所托非人。格雷格一直努力想要成为一个女演员，她偶然认识了导演戴维·塞维奇（Louis Jourdan）并与之谈起恋爱，有了塞维奇的帮助她以为自己已经可以全心追求演艺事业便放弃了秘书的工作，却未想到厄运已经就此埋下祸根。

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Shortly before he is to wed, millionaire John Willis is visited by Dr. Harry S. Blair, a psychiatrist who informs him that years before he was married to Nancy, John's wife-to-be, and warns him that she is mentally unbalanced.　　Blair then relates the following story After a whirlwind romance in Florida, Blair marries Nancy and starts a psychiatric practice in New York. One day, artist Norman Clyde comes to his office and tells him that an innocent man is about to be executed in Sing Sing Prison and that Nancy is the cause of his unjust incarceration. A distraught Clyde then explains himself to a curious Blair　　Three years before, Clyde meets Nancy, whose maiden name was Monks, when she enrolls in his art class. The moody Clyde soon falls in love with Nancy's honest charm and beauty. Nancy, a secretary, introduces Clyde to her boss, millionaire Andrew Bonner, and persuades Bonner to showcase Clyde's paintings at one of his private showings. To Nancy's delight, Clyde's painting, a depiction of the tragic figure Cassandra for which she modeled, wins first prize at the showing. The evening is perfect until an expensive bracelet is stolen from a guest, and Clyde later finds it in Nancy's purse. After Clyde confronts a confused Nancy about the theft, she relates the following story to explain her behavior　　As a young girl, Nancy lives with her housekeeper mother in the lavish Willis home and plays with Karen, the Willises' little daughter. Although Karen wants to invite Nancy to her upcoming birthday party, Mrs. Willis refuses to allow the lower-class Nancy to attend. A true friend, Karen promises to give Nancy one of the pins her guests are receiving. When Karen realizes there are no extra pins, however, she offers Nancy the beautiful locket she has just received from her mother. Nancy's subsequent joy is soon crushed when Mrs. Willis demands that she return the locket. Later, the locket is discovered missing, and Nancy is accused of theft. Although Nancy's mother soon finds the locket in Karen's dress, Mrs. Willis refuses to believe Nancy and forces her to confess.　　The adult Nancy then admits to Clyde that this childhood humiliation caused her unconscious desire to steal the bracelet at the party. After a forgiving Clyde returns the bracelet anonymously, he and Nancy continue their romance until the next party at the Bonners'. Suspecting that the absent Nancy is spending the evening in Bonner's arms, Clyde leaves the party to look for her and sees her exiting Mrs. Bonner's bedroom just after two gunshots are fired. Bonner is found murdered, and Mrs. Bonner's diamond necklace, stolen. Although Nancy and Clyde are questioned, valet Myron Dexter is eventually found guilty and is sentenced to die. Clyde, however, strongly suspects Nancy, but she angrily maintains her innocence and leaves for Florida.　　Back in his office, Blair defends Nancy to Clyde but invites him to his house that evening. When confronted, Nancy denies everything and tells Blair that Clyde is merely jealous. The next day, Dexter is executed, and a guilt-ridden Clyde jumps from Blair's office window to his death.　　To avoid scandal, Blair and Nancy move to England, and after World War II breaks out, Blair volunteers his medical services, while Nancy becomes an ambulance driver. Expressing concern over Blair's health, Nancy insists that they take a vacation at Lord and Lady Wyndham's manor house. Just as they are leaving, Blair learns that one of Lady Wyndham's valuable jewels has been stolen. Blair suspects Nancy but is unable to prove anything until a bomb destroys their flat and reveals her cache of stolen jewels.　　Although confronted directly, Nancy continues to deny any guilt and divorces Blair after he suffers a nervous breakdown. Back in John's study, Blair, like Clyde before him, tries to convince John to abandon Nancy, who now uses the name Patton. John, however, believes Nancy when she tells him that Blair is still suffering from his breakdown.　　Moments before the wedding is to start, Nancy's future mother-in-law, the unsuspecting Mrs. Willis, gives her the same locket that she once took away, and tells her that it is a precious family heirloom. The locket causes Nancy to be overcome with guilt, and she collapses at the altar in hysterics. As Nancy is later taken away to an institution, John sadly realizes the truth of Blair's story, but determines to see Nancy through her crisis.